Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

Adriaan H. de Wilde, Dirk Jochmans, Clara C. Posthuma, +6

Antimicrobial Agents and Chemotherapy

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

Eric J. Snijder, Ronald W.A.L. Limpens, Adriaan H. de Wilde, +6

PLoS Biology

Viral ReplicationImmunologyViral PathogenesisMolecular BiologyViral Structural Protein +15

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

Rinke Bos, Lucy Rutten, Joan E. M. van der Lubbe, +21

npj Vaccines

ImmunologyImmunodominanceImmunotherapeuticsViral Structural ProteinViral Surface Spike +16

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Adriaan H. de Wilde, V. Stalin Raj, Diede Oudshoorn, +9

Journal of General Virology

Viral ReplicationMicrobial PathogensViral PathogenesisImmunologyPathology +15

Cyclosporin A inhibits the replication of diverse coronaviruses

Adriaan H. de Wilde, Jessika C. Zevenhoven-Dobbe, Yvonne van der Meer, +5

Journal of General Virology

Csa TreatmentViral ReplicationViral PersistenceMolecular VirologyPathogenesis +11

A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis

Eric J. Snijder, Ronald W.A.L. Limpens, Adriaan H. de Wilde, +6

Viral ReplicationViral Polymerase StructureViral Polymerase MechanismViral PathogenesisMolecular Biology +17

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

Hannah L. Peters, Dirk Jochmans, Adriaan H. de Wilde, +4

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicineAntiviral Drug DevelopmentOrganic ChemistryChemistry +6

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model

Adriaan H. de Wilde, Darryl Falzarano, Jessika C. Zevenhoven-Dobbe, +7

Virus Research

A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins

Adriaan H. de Wilde, Kazimier F. Wannee, Florine E. M. Scholte, +5

Journal of Virology

Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP

Laura Solforosi, Harmjan Kuipers, Mandy Jongeneelen, +40

The Journal of Experimental Medicine