Clara C. Posthuma

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

Adriaan H. de Wilde, Dirk Jochmans, Clara C. Posthuma et al. · Antimicrobial Agents and Chemotherapy · 2014 · 750 citations · Full text

Medicine, Infectious Diseases, Pharmacology +12

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Lorenzo Subissi, Clara C. Posthuma, Axelle Collet et al. · Proceedings of the National Academy of Sciences · 2014 · 644 citations

Life Sciences, Infectious Diseases, Molecular Biology +17

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Adriaan H. de Wilde, V. Stalin Raj, Diede Oudshoorn et al. · Journal of General Virology · 2013 · 359 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +17

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Natacha S. Ogando, Jessika C. Zevenhoven-Dobbe, Yvonne van der Meer et al. · Journal of Virology · 2020 · 301 citations · Full text

Life Sciences, Biology, Infectious Diseases +17

Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production

Andrew E. Firth, Jessika C. Zevenhoven-Dobbe, Norma M. Wills et al. · Journal of General Virology · 2011 · 300 citations · Full text

Life Sciences, Biology, Molecular Biology +17