Inactivation of specific β cell transcription factors in type 2 diabetes

Shuangli Guo, Chunhua Dai, Min Guo, +6

Journal of Clinical Investigation

Insulin ResistanceRedox SignalingTranscriptional RegulationSignal TransductionDiabetes +11

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

Aharon Helman, Agnes Klochendler, Narmen Azazmeh, +18

Nature Medicine

Signal TransductionDiabetesCellular SenescenceP16ink4a-induced SenescenceMedicine +3

Purification of human blood burst‐forming units‐erythroid and demonstration of the evolution of erythropoietin receptors

K Sawada, Sanford B. Krantz, Chunhua Dai, +4

Journal of Cellular Physiology

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

H. Efsun Arda, Lingyu Li, Jennifer Tsai, +16

Cell Metabolism

Developmental BiologyMolecular PhysiologySignal TransductionLongevityCellular Senescence +4

Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia

Christine Longuet, Ana M. Robledo, E. Danielle Dean, +8

Diabetes

PathologyMurine Glucagon ReceptorGlucose ToleranceCellular PhysiologyInsulin Signaling +21

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Marcela Briššová, Rachana Haliyur, Diane C. Saunders, +20

Cell Reports

Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

Chunhua Dai, Sanford B. Krantz

Blood

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

Marcela Briššová, Kristie Aamodt, Priyanka Brahmachary, +9

Cell Metabolism

Regenerative MedicineDevelopmental BiologyAngiogenesisIslet MicroenvironmentBiological Microenvironments +4

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation

E. Danielle Dean, Mingyu Li, Nripesh Prasad, +25

Cell Metabolism

Signal TransductionHepatologyMolecular PhysiologyLiver Physiologyα Cell Proliferation +6

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

Katie C. Coate, Jeeyeon Cha, Shristi Shrestha, +16

Cell Metabolism

Human PancreasPancreatic CancerTmprss2 AreImmunologyPathology +7