Yasuhisa Nagasaka

ASP4058, a Novel Agonist for Sphingosine 1-Phosphate Receptors 1 and 5, Ameliorates Rodent Experimental Autoimmune Encephalomyelitis with a Favorable Safety Profile

Rie Yamamoto, Youhei Okada, Jun Hirose et al. · PLoS ONE · 2014 · 32 citations · Full text

Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood–brain barrier

Yasuhisa Nagasaka, Kazuo Oda, Takafumi Iwatsubo et al. · Biopharmaceutics & Drug Disposition · 2012 · 25 citations

Drug Efflux Transporters, Gastrointestinal Pharmacology, Inhibition Potencies +19

Human mass balance, metabolite profile and identification of metabolic enzymes of [¹⁴C]ASP015K, a novel oral janus kinase inhibitor

Kazuo Oda, Ying Cao, Taiji Sawamoto et al. · Xenobiotica · 2015 · 23 citations

Metabolomic Profiling, Physiologically-based Pharmacokinetic Modeling, Metabolite Profile +23

Modeling of Blood–Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research

Masato Ohbuchi, Mayu Shibuta, Kazuhiro Tetsuka et al. · International Journal of Molecular Sciences · 2024 · 19 citations · Full text

Immunology, Barrier Dysfunction, Biomedical Engineering +21

Virtual clinical trial simulations for a novel KRAS^G12C inhibitor (ASP2453) in non‐small cell lung cancer

Hiroyuki Sayama, Diana H. Marcantonio, Takeyuki Nagashima et al. · CPT Pharmacometrics & Systems Pharmacology · 2021 · 15 citations · Full text