Pim W. van der Helm

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

Kendall J. Condon, Jose M. Orozco, Charles H. Adelmann et al. · Proceedings of the National Academy of Sciences · 2021 · 131 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer

Joris van de Haar, Xuhui Ma, Salo Ooft et al. · Nature Medicine · 2023 · 84 citations · Full text

Medicine, Oncology, Pharmacology +17

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

Zhengkui Zhang, Xiangjun Kong, Maarten A. Ligtenberg et al. · Cell Reports Medicine · 2022 · 44 citations · Full text

Life Sciences, Immunology, Oncology +17

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

Chun‐Pu Lin, Pierre Lévy, Astrid Alflen et al. · Cancer Cell · 2024 · 17 citations · Full text

Life Sciences, Genetics, Immunology +16

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

Kendall J. Condon, Jose M. Orozco, Charles H. Adelmann et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 15 citations · Full text

Life Sciences, Genetics, Molecular Biology +17