Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

Özgür Şahin, Holger Fröhlich, Christian Löbke, +11

BMC Systems Biology

Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model

Janina Kuen, Diana Darowski, Tobias Kluge, +1

PLoS ONE

M2 PhenotypeImmunologyBiological MicroenvironmentsTherapeutic ResponseCell Proliferation +15

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis

Peter Brünker, Katharina Wartha, Thomas Friess, +24

Molecular Cancer Therapeutics

Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model

Meher Majety, Leon P. Pradel, Manuela Gies, +1

PLoS ONE

Biological MicroenvironmentsTherapeutic ResponseCell CultureCell ProliferationCancer Biology +15

Human Retroviral gag- and gag-pol-like Proteins Interact with the Transforming Growth Factor-β Receptor Activin Receptor-like Kinase 1

Andreas Lux, Christian Beil, Meher Majety, +7

Journal of Biological Chemistry

A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity

Raffaella Castoldi, Veronika Ecker, Laura Wiehle, +12

Oncogene

Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells

Mamatha Sauermann, Özgür Şahin, Holger Sültmann, +8

Oncogene

MedicineCell InteractionInvasion CapacityTumor CellsCellular Physiology +9

Urokinase-type plasminogen activator induces proliferation in breast cancer cells

Mukesh Gandhari, Norbert Arens, Meher Majety, +2

International Journal of Oncology

Extracellular Matrix TurnoverMedicineReceptor Tyrosine KinaseBreast Cancer CellsImmunology +11

Statistical methods and software for the analysis of highthroughput reverse genetic assays using flow cytometry readouts

Florian Hahne, Dorit Arlt, Mamatha Sauermann, +4

Genome biology

Functional Profiling: From Microarrays via Cell-Based Assays to Novel Tumor Relevant Modulators of the Cell Cycle

Dorit Arlt, Wolfgang Huber, Urban Liebel, +18

Cancer Research