W. David Church

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan Abo et al. · Cancer Cell · 2021 · 171 citations

Cytokine, Cancer Immunosurveillance, Medicine +9

A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants

Laurie B. Schenkel, Jennifer R. Molina, Kerren K. Swinger et al. · Cell chemical biology · 2021 · 71 citations · Full text

Inflammation, Selective Parp14 Inhibitor, Inflammatory Responses +10

In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement

Tim J. Wigle, Danielle J. Blackwell, Laurie B. Schenkel et al. · Cell chemical biology · 2020 · 24 citations · Full text

Signal Transduction, Protein Expression, Biochemistry +10

Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes

Tim J. Wigle, W. David Church, Christina R. Majer et al. · SLAS DISCOVERY · 2019 · 23 citations · Full text

Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule

Tim J. Wigle, Yue Ren, Jennifer R. Molina et al. · ChemBioChem · 2021 · 23 citations