Cassandra Koole

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova et al. · Nature · 2018 · 325 citations · Full text

Molecular Pharmacology, Signal Transduction, Molecular Physiology +7

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Yi-Lynn Liang, Maryam Khoshouei, Giuseppe Deganutti et al. · Nature · 2018 · 255 citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +8

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

Cassandra Koole, Denise Wootten, John Simms et al. · Molecular Pharmacology · 2010 · 223 citations

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Denise Wootten, Christopher A. Reynolds, Kevin J. Smith et al. · Cell · 2016 · 155 citations · Full text

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

Yi-Lynn Liang, Matthew J. Belousoff, Peishen Zhao et al. · Molecular Cell · 2020 · 122 citations · Full text

Signal Transduction, Biochemistry, Structural Understanding +7