Aaron Janoff

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

Aaron Janoff, Joel Scherer · The Journal of Experimental Medicine · 1968 · 452 citations · Full text

Immunology, Protein Purification, Inflammation +16

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

H. Carp, Aaron Janoff · PubMed · 1978 · 358 citations

Asthma, Tobacco Control, Biochemistry +14

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

H. Carp, Frederick W. Miller, John R. Hoidal et al. · Proceedings of the National Academy of Sciences · 1982 · 344 citations · Full text

Asthma, Methionine Sulfoxide, Methionine Oxidation +17

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

H. Carp, Aaron Janoff · Journal of Clinical Investigation · 1979 · 290 citations · Full text

Lipid Peroxidation, Immunology, Blood Cell +20

Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease.

Aaron Janoff, Barbara Sloan, George Weinbaum et al. · PubMed · 1977 · 281 citations

Inflammatory Lung Disease, Lung Inflammation, Pmn Elastase +20