Leila N. Varghese

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand et al. · Immunity · 2013 · 1.2K citations · Full text

Protein Function, Signal Transduction, Medicine +14

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

James M. Murphy, Qingwei Zhang, Samuel N. Young et al. · Biochemical Journal · 2013 · 280 citations · Full text

Engineering, Molecular Biology, Biological Computing +25

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Nadia J. Kershaw, James M. Murphy, Nicholas P. D. Liau et al. · Nature Structural & Molecular Biology · 2013 · 277 citations

Cytokine, Signal Transduction, Signaling Pathway +12

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Jeffrey J. Babon, Nadia J. Kershaw, James M. Murphy et al. · Immunity · 2012 · 256 citations · Full text

Inflammation, Cytokine, Signal Transduction +13

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Maurice Labuhn, Kelly Perkins, Sören Matzk et al. · Cancer Cell · 2019 · 140 citations · Full text

Down Syndrome, Myeloid Preleukemia, Transformed Myeloid Leukemia +8