Harunobu Mukaiyama

The importance of CH/π hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase

Tomonaga Ozawa, Eiichi Tsuji, Motoyasu Ozawa et al. · Bioorganic & Medicinal Chemistry · 2008 · 73 citations · Full text

Drug Target, Biochemistry, Drug Design +8

Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke

Harunobu Mukaiyama, Toshihiro Nishimura, Satoko Kobayashi et al. · Bioorganic & Medicinal Chemistry · 2006 · 53 citations · Full text

Medicinal Chemistry, Biochemistry, C-src Inhibitory Activity +9

Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade

Harunobu Mukaiyama, Toshihiro Nishimura, Satoko Kobayashi et al. · Bioorganic & Medicinal Chemistry · 2007 · 43 citations · Full text

Biochemistry, Medicine, Pharmacological Agent +7

A novel Syk family kinase inhibitor: Design, synthesis, and structure–activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives

Akihito Hirabayashi, Harunobu Mukaiyama, Hiroaki Kobayashi et al. · Bioorganic & Medicinal Chemistry · 2008 · 41 citations · Full text

Structure–activity Relationship, Molecular Pharmacology, Medicinal Chemistry +8

Structure–activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors

Akihito Hirabayashi, Harunobu Mukaiyama, Hiroaki Kobayashi et al. · Bioorganic & Medicinal Chemistry · 2008 · 34 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Derivatives +12