α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

Shangang Zhao, Yves Mugabo, José Iglesias, +12

Cell Metabolism

Metabolic SyndromeBiochemistryDiabetesMetabolic SignalingMedicine +1

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

Yves Mugabo, Shangang Zhao, Annegrit Seifried, +12

Proceedings of the National Academy of Sciences

Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice

Ja Young Kim-Muller, Shangang Zhao, Shekhar Srivastava, +8

Cell Metabolism

ObesityMetabolic SyndromeTriple Foxo-deficient MiceGeneticsDiabetes +10

α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes

Shangang Zhao, Yves Mugabo, Gwynne Ballentine, +14

Cell Reports

Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells

Yves Mugabo, Shangang Zhao, Julien Lamontagne, +6

Journal of Biological Chemistry

Metabolic RemodelingInsulin SignalingMetabolic SyndromePancreatic CancerExcess Fuels +16

α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

Shangang Zhao, Pegah Poursharifi, Yves Mugabo, +8

Molecular Metabolism

Adipose ABHD6 regulates tolerance to cold and thermogenic programs

Pegah Poursharifi, Camille Attané, Yves Mugabo, +14

JCI Insight

Oxidative StressObesityMetabolic SyndromeBody CompositionAdipose Abhd6 +18

Palmitate induces C-reactive protein expression in human aortic endothelial cells. Relevance to fatty acid–induced endothelial dysfunction

Yves Mugabo, Yvette Mukaneza, Geneviève Renier

Metabolism

InflammationMetabolic SyndromeVascular DiseaseCardiovascular DiseaseMedicine +8

Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis

Yves Mugabo, Mina Sadeghi, Nancy N. Fang, +2

Journal of Biological Chemistry

Rna-splicing FactorsNatural SciencesRna SplicingRna BiologyMolecular Biology +7

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Yves Mugabo, Cheng Zhao, Ju Jing Tan, +12

JCI Insight

14-3-3 ProteinsInsulin SignalingCellular PhysiologySignaling PathwayMetabolic Signaling +14