MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

Manpreet Kalkat, Diana Resetca, Corey Lourenco, +10

Molecular Cell

MedicineCancer GenomicsCell-matrix InteractionTumor SuppressorSystems Biology +4

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

Dharmendra Dingar, Manpreet Kalkat, Pak-Kei Chan, +11

Journal of Proteomics

Cultured CellsOncogenic AgentMedicineBioid IdentifiesXenograft Tumors +5

DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse

Wanding Zhou, Toshinori Hinoue, Bret Barnes, +25

Cell Genomics

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

Aleksandra A. Pandyra, Peter Mullen, Manpreet Kalkat, +8

Cancer Research

Chemoprevention StrategyFda-approved StatinsPharmacotherapyMetabolic RemodelingTumor Biology +18

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

Aleksandra A. Pandyra, Peter Mullen, Carolyn A. Goard, +13

Oncotarget

Placental autophagy regulation by the BOK-MCL1 rheostat

Manpreet Kalkat, Julia Garcia, Jessica Ebrahimi, +4

Autophagy

MitophagyBcl2 FamilyTrigger AutophagyApoptosisImmunology +16

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

Dharmendra Dingar, William B. Tu, Diana Resetca, +9

Nature Communications

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth

Lindsay C. Lustig, Dharmendra Dingar, William B. Tu, +7

Oncogene

Tumor BiologyChromatinOncogenic AgentMedicineMyc Binding +9

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Amanda R. Wasylishen, Michelle Chan‐Seng‐Yue, Christina Bros, +10

Cancer Research

Systems BiologySignal TransductionCell RegulationMyc PhosphorylationMedicine +12

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Andrew M. Waters, Tala O. Khatib, Bjoern Papke, +34

Cell Reports