Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

Masayoshi Ohkuro, Jun‐Dal Kim, Yoshikazu Kuboi, +23

Nature Communications

Chronic Inflammatory DiseasesGastrointestinal PharmacologyImmunologyGastroenterologyPathology +21

Role of Anti‐Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis

Kana Hoshino‐Negishi, Masayoshi Ohkuro, Tomoya Nakatani, +12

Arthritis & Rheumatology

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead

Hong Du, Tomohiro Matsushima, Mark R. Spyvee, +29

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAnti-inflammatoryBiochemistryNatural SciencesMedicine +7

Blockade of the fractalkine–CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes

Yoshikazu Kuboi, Miyuki Nishimura, Wataru Ikeda, +12

International Immunology

Characterization of 5′-flanking region of human aggrecanase-1 (ADAMTS4) gene

Yoshiharu Mizui, Kazuto Yamazaki, Yoshikazu Kuboi, +2

Molecular Biology Reports

E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis

Hisashi Wakita, Tatsuya Yanagawa, Yoshikazu Kuboi, +1

Molecular Pharmacology

Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice

Satoshi Mizutani, Junko Nishio, Kanoh Kondo, +11

Pharmaceuticals

Inflammatory Lung DiseaseLung InflammationImmunologyPathologyImmunologic Mechanism +18

E6201, a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase-1 and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase-1: In Vivo Effects on Cutaneous Inflammatory Responses by Topical Administration

Kenzo Muramoto, Masaki Goto, Yoko Inoue, +7

Journal of Pharmacology and Experimental Therapeutics

Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the <scp>CX</scp>₃<scp>CL</scp>1/<scp>CX</scp>₃<scp>CR</scp>1 Pathway in Experimental Mouse Models of Systemic Sclerosis

Vu Huy Luong, Akira Utsunomiya, Takenao Chino, +12

Arthritis & Rheumatology

Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time

Sotaro Motoi, Hiroko Toyoda, Takashi Obara, +10

International Journal of Molecular Sciences

ImmunologyPathologyCell DeathCirrhosisOxidative Stress +21