Pluronic–PEI copolymers enhance exon-skipping of 2′-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice

M Wang, Bo Wu, Peijuan Lu, +4

Gene Therapy

Nucleic Acid ChemistryMolecular NeuroscienceNatural SciencesOligonucleotideDna Replication +7

Poly(ester amine) constructed from polyethylenimine and pluronic for gene delivery <i>in vitro</i> and <i>in vivo</i>

Mingxing Wang, Bo Wu, Jason D. Tucker, +2

Drug Delivery

Tissue EngineeringEngineeringBiofabricationGene DeliveryBiomedical Engineering +15

Overexpression of Mutant FKRP Restores Functional Glycosylation and Improves Dystrophic Phenotype in FKRP Mutant Mice

Jason D. Tucker, Pei Lu, Xiao Xiao, +1

Molecular Therapy — Nucleic Acids

GlycobiologyMolecular BiologyDisease Gene IdentificationImproves Dystrophic PhenotypeCellular Physiology +25

Restoration of Functional Glycosylation of α-Dystroglycan in FKRP Mutant Mice Is Associated with Muscle Regeneration

Hiroyuki Awano, Anthony Blaeser, Elizabeth Keramaris, +5

American Journal Of Pathology

Regenerative MedicineBiochemistrySkeletal MuscleGlycobiologyFunctional Glycosylation +5

Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer

Jason D. Tucker, Ravi Doddapaneni, Pei Lu, +1

PLoS ONE

Breast OncologyCentral Carbon MetabolismChemoprevention StrategyGlycobiologyMetabolic Remodeling +24

Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model

Bo Wu, Morgan Drains, Sapana N. Shah, +7

PLoS ONE

Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth

Pei Lu, Jason D. Tucker, Elizabeth K. Branch, +3

Scientific Reports

Cationic polyelectrolyte-mediated delivery of&amp;nbsp;antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice

Mingxing Wang, Bo Wu, Jason D. Tucker, +2

International Journal of Nanomedicine

Improved efficacy of FKRP AAV gene therapy by combination with ribitol treatment for LGMD2I

Marcela P. Cataldi, Charles H. Vannoy, Anthony Blaeser, +5

Molecular Therapy

Tween 85 grafted PEIs enhanced delivery of antisense 2′-O-methyl phosphorothioate oligonucleotides in vitro and in dystrophic mdx mice

Mingxing Wang, Bo Wu, Jason D. Tucker, +3

Journal of Materials Chemistry B