Yoshihito Kano

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Severa Bunda, Kelly Burrell, Pardeep Heir et al. · Nature Communications · 2015 · 228 citations · Full text

Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis

Xiu Zheng, Kiichiro Tsuchiya, Ryuichi Okamoto et al. · Inflammatory Bowel Diseases · 2011 · 135 citations

Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation

Severa Bunda, Pardeep Heir, Tharan Srikumar et al. · Proceedings of the National Academy of Sciences · 2014 · 101 citations · Full text

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall et al. · Nature Communications · 2019 · 96 citations · Full text

PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

Federica Liotti, Narender Kumar, Nella Prevete et al. · Journal of Experimental & Clinical Cancer Research · 2021 · 82 citations · Full text