Yoshihito Kano

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Severa Bunda, Kelly Burrell, Pardeep Heir et al. · Nature Communications · 2015 · 242 citations · Full text

Medicine, Biochemistry, Oncology +17

Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis

Xiu Zheng, Kiichiro Tsuchiya, Ryuichi Okamoto et al. · Inflammatory Bowel Diseases · 2011 · 135 citations

Life Sciences, Molecular Biology, Molecular Genetics +17

Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation

Severa Bunda, Pardeep Heir, Tharan Srikumar et al. · Proceedings of the National Academy of Sciences · 2014 · 106 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall et al. · Nature Communications · 2019 · 102 citations · Full text

Life Sciences, Biochemistry, Oncology +17

PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

Federica Liotti, Narender Kumar, Nella Prevete et al. · Journal of Experimental & Clinical Cancer Research · 2021 · 85 citations · Full text

Medicine, Cancer Biology, Oncology +17