Christian Harcken

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen Venken, Peggy Jacques, Céline Mortier et al. · Nature Communications · 2018 · 306 citations · Full text

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

Nuruddeen D. Lewis, Lori Patnaude, Josephine Pelletier et al. · PLoS ONE · 2014 · 73 citations · Full text

Gpbar1 Agonist, Immunology, Immune Dysregulation +19

Improved <i>E</i>-Selectivity in the Wittig Reaction of Stabilized Ylides with α-Alkoxyaldehydes and Sugar Lactols

Christian Harcken, Stephen F. Martin · Organic Letters · 2001 · 65 citations

Engineering, Alkene Metathesis, Biochemistry +11

Synthesis of Optically Active Butenolides and γ‐Lactones by the Sharpless Asymmetric Dihydroxylation of β,γ‐Unsaturated Carboxylic Esters

Christian Harcken, Reinhard Brückner · Angewandte Chemie International Edition in English · 1997 · 63 citations

Ad Mix α, Natural Product Synthesis, Engineering +13

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients

Helena Bassolas-Molina, Ernest Raymond, Mark E. Labadia et al. · Frontiers in Immunology · 2018 · 47 citations · Full text