Isabelle Green

Structural Basis of Substrate Methylation and Inhibition of SMYD2

Andrew D. Ferguson, Nicholas Larsen, Tina Howard et al. · Structure · 2011 · 195 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Discovery of 5-Chloro-<i>N</i>²-[(1<i>S</i>)-1-(5-fluoropyrimidin-2-yl)ethyl]-<i>N</i>⁴-(5-methyl-1<i>H</i>-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Stephanos Ioannidis, Michelle L. Lamb, Tao Wang et al. · Journal of Medicinal Chemistry · 2010 · 123 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

Les A. Dakin, Huawei Chen, Erin Code et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 101 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Anna A. Marusiak, Natalie L. Stephenson, Hayeon Baik et al. · Cancer Research · 2015 · 49 citations · Full text

Medicine, Molecular Biology, Oncology +17

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

Catherine Bardelle, Bernard Barlaam, Nigel Brooks et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14