Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

Erin Dunbar, Bonnie S. Coats, Albert L. Shroads, +6

Investigational New Drugs

Neuro-oncologyMedicineMetronomic TherapyNeurologyHigh-grade Gliomas +6

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

Steven R. Davis, Peter W. Stacpoole, Jerry Williamson, +6

American Journal of Physiology-Endocrinology and Metabolism

Long-term safety of dichloroacetate in congenital lactic acidosis

Monica Abdelmalak, Alicia Lew, Ryan Ramezani, +7

Molecular Genetics and Metabolism

Congenital Lactic AcidosisNeonatologyPediatrics

Metabolite Profile Analysis Reveals Functional Effects of 28-Day Vitamin B-6 Restriction on One-Carbon Metabolism and Tryptophan Catabolic Pathways in Healthy Men and Women

Vanessa R. da Silva, Luisa Rios‐Avila, Yvonne Lamers, +12

Journal of Nutrition

NutritionMetabolic SyndromeOne-carbon MetabolismPhysiologyMetabolomic Profiling +11

Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men1–4

Steven R. Davis, Jennifer B Scheer, Eoin P. Quinlivan, +3

American Journal of Clinical Nutrition

Vitamin NutritionNutritionHomocysteine RemethylationNutrient PhysiologyMedicine +13

Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate

Albert L. Shroads, Taimour Langaee, Bonnie S. Coats, +8

The Journal of Clinical Pharmacology

GeneticsHuman PolymorphismMetabolomic ProfilingToxicological MechanismGstz1/maai Haplotype +19

The Methylenetetrahydrofolate Reductase 677C→T Polymorphism and Dietary Folate Restriction Affect Plasma One-Carbon Metabolites and Red Blood Cell Folate Concentrations and Distribution in Women

Steven R. Davis, Eoin P. Quinlivan, Karla P. Shelnutt, +10

Journal of Nutrition

Methylenetetrahydrofolate Reductase 677C→tNutritionMetabolic SyndromeMetabolic DisorderGenetics +7

Homocysteine Synthesis Is Elevated but Total Remethylation Is Unchanged by the Methylenetetrahydrofolate Reductase 677C→T Polymorphism and by Dietary Folate Restriction in Young Women

Steven R. Davis, Eoin P. Quinlivan, Karla P. Shelnutt, +10

Journal of Nutrition

NutritionBiochemistryGeneticsClinical NutritionMolecular Nutrition +8

Marginal Vitamin B-6 Deficiency Decreases Plasma (n-3) and (n-6) PUFA Concentrations in Healthy Men and Women3

Mei Zhao, Yvonne Lamers, Maria Ralat, +8

Journal of Nutrition

Vitamin NutritionNutritionNutrient PhysiologyNutritional RequirementVitamin B Complex +7

Moderate Vitamin B-6 Restriction Does Not Alter Postprandial Methionine Cycle Rates of Remethylation, Transmethylation, and Total Transsulfuration but Increases the Fractional Synthesis Rate of Cystathionine in Healthy Young Men and Women1–3

Yvonne Lamers, Bonnie S. Coats, Maria Ralat, +3

Journal of Nutrition

NutritionFractional Synthesis RateMedicineClinical NutritionPharmacology +7