Dianna Lester-Zeiner

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors

Darin J. Gustin, Zhihua Ma, Xiaoshan Min et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 48 citations · Full text

Medicinal Chemistry, Noncovalent Fatty Acid, Aldehyde Dehydrogenase +9

Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

Essa Hu, Roxanne K. Kunz, Ning Chen et al. · Journal of Medicinal Chemistry · 2013 · 43 citations · Full text

Drug Target, Pharmacotherapy, Chemical Biology +17

Discovery of Clinical Candidate 1-(4-(3-(4-(1<i>H</i>-Benzo[<i>d</i>]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

Essa Hu, Ning Chen, Matthew P. Bourbeau et al. · Journal of Medicinal Chemistry · 2014 · 36 citations · Full text

Clinical Candidate, Pharmacotherapy, Pde10a Clinical Candidate +17

Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

Essa Hu, Ji Ma, Christopher Biorn et al. · Journal of Medicinal Chemistry · 2012 · 28 citations · Full text

Molecular Biology, Tracer Candidate, Molecular Characterization +19

Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity

Derin C. D’Amico, Toshi Aya, Jason Human et al. · Journal of Medicinal Chemistry · 2007 · 26 citations · Full text

Conformational Entropy, Immunology, Pharmacotherapy +17