Celeste Giansanti

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma

Isabelle Roeschert, Evon Poon, Anton G. Henssen et al. · Nature Cancer · 2021 · 100 citations · Full text

Mycn-amplified Neuroblastoma, Radiation Oncology, Medicine +2

MYC multimers shield stalled replication forks from RNA polymerase

Daniel Solvie, Apoorva Baluapuri, Leonie Uhl et al. · Nature · 2022 · 85 citations

Rna Processing, Transcriptional Regulation, Rna Polymerase +1

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

Dimitrios Papadopoulos, Daniel Solvie, Apoorva Baluapuri et al. · Molecular Cell · 2021 · 57 citations

Chromatin, Transcriptional Regulation, Rna Processing +14

MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

Celeste Giansanti, Valentina Manzini, Antje Dickmanns et al. · Cell Reports · 2022 · 27 citations · Full text

Chromatin, Genome Instability, Functional P53 +12

Mdm4 supports DNA replication in a p53-independent fashion

Kai Wohlberedt, Ina Klusmann, Polina K. Derevyanko et al. · Oncogene · 2020 · 23 citations · Full text

Molecular Biology, Natural Sciences, Genome Instability +1