Yasuro KAWAGUCHI

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima et al. · PubMed · 2000 · 165 citations

Chemical Biology, Toxicological Mechanism, Medicinal Chemistry +16

Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.

Haruhiro Okuda, Takahito Nishiyama, Kenichiro Ogura et al. · PubMed · 1997 · 106 citations

Immunotoxicology, Oral 5-Fluorouracil Prodrugs, Immunology +20

Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.

Takao Komatsu, Hiroshi Yamazaki, Noriaki Shimada et al. · PubMed · 2001 · 48 citations

Pathology, Mm Tegafur, 5-Fluorouracil Formation +21

Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine

Kenichiro Ogura, Takahito Nishiyama, Hiroaki Takubo et al. · Cancer Letters · 1998 · 40 citations

Suicidal Inactivation, Biochemistry, Pharmacology +2

Tissue Distribution and Biotransformation of Potassium Oxonate after Oral Administration of a Novel Antitumor Agent (Drug Combination of Tegafur, 5-Chloro-2,4-dihydroxypyridine, and Potassium Oxonate) to Rats

Kunihiro Yoshisue, Hirotoshi MASUDA, Eiji Matsushima et al. · Drug Metabolism and Disposition · 2000 · 34 citations