Lachlan Clydesdale

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova et al. · Nature · 2018 · 332 citations · Full text

Life Sciences, Biochemistry, Pharmacology +12

Activation of the GLP-1 receptor by a non-peptidic agonist

Peishen Zhao, Yi-Lynn Liang, Matthew J. Belousoff et al. · Nature · 2020 · 168 citations · Full text

Life Sciences, Endocrinology, Pharmacology +14

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang et al. · Nature Communications · 2022 · 84 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

Marlies V. Hager, Lachlan Clydesdale, Samuel H. Gellman et al. · Biochemical Pharmacology · 2017 · 61 citations

Medicine, Molecular Biology, Pharmacology +16

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Madeleine M. Fletcher, Michelle L. Halls, Peishen Zhao et al. · Biochemical Pharmacology · 2018 · 58 citations

Life Sciences, Endocrinology, Physiology +14