Structure of an unliganded simian immunodeficiency virus gp120 core

Bing Chen, Erik Vogan, Haiyun Gong, +3

Nature

Virus StructureHuman RetrovirusImmunologyVirologyHiv +3

Structure of the Sec23p/24p and Sec13p/31p complexes of COPII

Gerardo Z. Lederkremer, Yifan Cheng, Benjamin M. Petre, +5

Proceedings of the National Academy of Sciences

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

Qi Wang, Erik Vogan, Laura M. Nocka, +4

eLife

Autoinhibited BtkMolecular PhysiologySignal TransductionBiochemistrySoluble Inositol Hexakisphosphate +13

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90

Ariamala Gopalsamy, Mengxiao Shi, Jennifer M. Golas, +13

Journal of Medicinal Chemistry

Atp Binding PocketDrug TargetProtein AssemblyBiomolecular Structure PredictionStructural Bioinformatics +15

Determining the Structure of an Unliganded and Fully Glycosylated SIV gp120 Envelope Glycoprotein

Bing Chen, Erik Vogan, Haiyun Gong, +3

Structure

GlycoproteomicsProtein GlycosylationBiochemistryNatural SciencesGlycobiology +7

Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model

Christoph W. Zapf, Jonathan D. Bloom, Zhong Li, +12

Bioorganic & Medicinal Chemistry Letters

Mouse Xenograft ModelTumor BiologyMedicineAnti-cancer AgentCancer Treatment +5

Crystal Structure at 1.8 Å Resolution of CDP-<scp>d</scp>-Glucose 4,6-Dehydratase from <i>Yersinia pseudotuberculosis</i>^,

Erik Vogan, Cornelia Bellamacina, Xuemei He, +3

Biochemistry

Crystal StructureSdr EnzymesReactive ArthritisHydride TransferCellular Enzymology +13

Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity

Christoph W. Zapf, Jonathan D. Bloom, Jamie L. McBean, +12

Bioorganic & Medicinal Chemistry Letters

Macrocyclic Hsp90 InhibitorsDrug TargetMedicineRational Drug DesignPotent Cell-proliferation Activity +7

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model

Christoph W. Zapf, Jonathan D. Bloom, Jamie L. McBean, +7

Bioorganic & Medicinal Chemistry Letters

Mouse Xenograft ModelDrug TargetBiomarker ActivityBiochemistryMedicine +6

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity

Christoph W. Zapf, Jonathan D. Bloom, Jamie L. McBean, +11

Bioorganic & Medicinal Chemistry Letters

Macrocyclic LactamsExcellent Tumor ExposureMedicinePharmacotherapyAnti-cancer Agent +7