Alisje Churchyard

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

Stanley C. Xie, Riley D. Metcalfe, Elyse Dunn et al. · Science · 2022 · 56 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Antimalarial Pyrido[1,2-<i>a</i>]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Kawaljit Singh, John Okombo, Christel Brunschwig et al. · Journal of Medicinal Chemistry · 2017 · 45 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

Laura E. de Vries, Patrick A.M. Jansen, Catalina Barceló et al. · Nature Communications · 2022 · 41 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

A Novel Pyrazolopyridine with in Vivo Activity in <i>Plasmodium berghei</i>- and <i>Plasmodium falciparum</i><i>-</i>Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

Claire Le Manach, Tanya Paquet, Christel Brunschwig et al. · Journal of Medicinal Chemistry · 2015 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design of proteasome inhibitors with oral efficacy in vivo against <i>Plasmodium falciparum</i> and selectivity over the human proteasome

Stanley C. Xie, Riley D. Metcalfe, Hirotake Mizutani et al. · Proceedings of the National Academy of Sciences · 2021 · 37 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17