Clemens Muehlan

The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468

Alexander Treiber, Ruben de Kanter, Catherine Roch et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 81 citations · Full text

Accelerated Development of the Dual Orexin Receptor Antagonist ACT‐541468: Integration of a Microtracer in a First‐in‐Human Study

Clemens Muehlan, Jules A. A. C. Heuberger, Pierre‐Éric Juif et al. · Clinical Pharmacology & Therapeutics · 2018 · 65 citations · Full text

Multiple-dose clinical pharmacology of ACT-541468, a novel dual orexin receptor antagonist, following repeated-dose morning and evening administration

Clemens Muehlan, Sander Brooks, Rob Zuiker et al. · European Neuropsychopharmacology · 2019 · 54 citations

Multiple-dose Clinical Pharmacology, Allergy, Medicine +7

Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration

Clemens Muehlan, Margaux Boehler, Sander Brooks et al. · Journal of Psychopharmacology · 2019 · 33 citations

Driving Performance after Bedtime Administration of Daridorexant, Assessed in a Sensitive Simulator

Clemens Muehlan, Sander Brooks, Cédric Vaillant et al. · Clinical Pharmacology & Therapeutics · 2022 · 31 citations · Full text

Placebo-corrected Mean, Sleep Medicine, Sleep +14