Herbert E. Klei

Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Louis J. Lombardo, Francis Y. Lee, Ping Chen et al. · Journal of Medicinal Chemistry · 2004 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +13

The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants

John S. Tokarski, John A. Newitt, Chieh Ying J. Chang et al. · Cancer Research · 2006 · 686 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Destruction of aromatic pollutants by UV light catalyzed oxidation with hydrogen peroxide

D. W. Sundstrom, Barbara A. Weir, Herbert E. Klei · Environmental Progress · 1989 · 149 citations

Natural Sciences, Chemistry, Environmental Sciences +17

Automated ligand fitting by core-fragment fitting and extension into density

Thomas C. Terwilliger, Herbert E. Klei, Paul D. Adams et al. · Acta Crystallographica Section D Biological Crystallography · 2006 · 129 citations · Full text

Life Sciences, Biochemistry, Chemistry +9

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

William J. Metzler, Joseph Yanchunas, Carolyn A. Weigelt et al. · Protein Science · 2008 · 128 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17