Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Zhihao Lü, Jianling Zou, Shuang Li, +45

Nature

Epigenetic ChangeEpigenomicsPremetastatic NichesMedicineCell Biology +2

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

Limin Xia, Wenjie Huang, Marina A. Bellani, +13

Cancer Cell

ChromatinMedicineGeneticsEpigenetic ChangeEpigenomics +8

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis

Yong Tao, Byunghak Kang, Daniel Petkovich, +23

Cancer Cell

ChromatinLineage PlasticityMedicineEpigenetic ChangeEpigenomics +8

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Xiangqian Kong, Jie Chen, Wenbing Xie, +15

Cancer Cell

ChromatinEpigenetic ChangeGeneticsEpigenomicsColorectal Cancer +7

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Yang W. Zhang, Zhihong Wang, Wenbing Xie, +7

Molecular Cell

ChromatinTranscriptional RegulationBiochemistryNatural SciencesEpigenetic Change +9

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

Wenbing Xie, Te Ling, Yonggang Zhou, +5

Proceedings of the National Academy of Sciences

Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologyRrna Genes +18

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

Wenbing Xie, Ioannis Kagiampakis, Lixia Pan, +13

Cancer Cell

ChromatinTransformation PotentialEpigenetic ChangeGeneticsDna Methylation +7

NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells

Min Luo, Te Ling, Wenbing Xie, +12

Stem Cells

Epigenetic ChangeAdult Stem CellEpigeneticsPluripotent Stem CellsInduced Pluripotent Stem Cells +20

DNA methylation in senescence, aging and cancer

Wenbing Xie, Stephen B. Baylin, Hariharan Easwaran

Oncoscience

ChromatinEpigenetic ChangeGeneticsDna MethylationEpigenomics +5

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1

Fei Ye, Xiangqian Kong, Hao Zhang, +17

ACS Chemical Biology