Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

Heather M. O’Hagan, Wei Wang, Subhojit Sen, +10

Cancer Cell

Polycomb MembersChromatinTranscriptional RegulationNatural SciencesGenetics +10

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

Minmin Liu, Hitoshi Ohtani, Wanding Zhou, +8

Proceedings of the National Academy of Sciences

Oncogenic AgentMedicinePathogenesisImmunologyAntiviral Response +12

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

Limin Xia, Wenjie Huang, Marina A. Bellani, +13

Cancer Cell

ChromatinMedicineGeneticsEpigenetic ChangeEpigenomics +8

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Yang W. Zhang, Zhihong Wang, Wenbing Xie, +7

Molecular Cell

ChromatinTranscriptional RegulationBiochemistryNatural SciencesEpigenetic Change +9

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

Wenbing Xie, Ioannis Kagiampakis, Lixia Pan, +13

Cancer Cell

ChromatinTransformation PotentialEpigenetic ChangeGeneticsDna Methylation +7

Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

Ludovic Zimmerlin, Tea Soon Park, Jeffrey S. Huo, +14

Development

Adult Stem CellNaïve StatesChemical BiologyEpigeneticsCellular Physiology +20

Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

Yi Cai, Hsing-Chen Tsai, Ray-Whay Chiu Yen, +5

Genome Research

Histone ModificationsEpigenetic ChangeGeneticsDna MethylationEpigenetics +16

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors

Hong Lin, Min Wang, Yang W. Zhang, +5

ACS Medicinal Chemistry Letters

Drug TargetBioorganic ChemistryAldo-keto ReductaseMolecular BiologyChemical Biology +14

PRMT5 regulates T cell interferon response and is a target for acute graft-versus-host disease

Katiri Snyder, Nina C. Zitzer, Yandi Gao, +17

JCI Insight

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1

Fei Ye, Xiangqian Kong, Hao Zhang, +17

ACS Chemical Biology