Filip Zemek

Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease

Jan Korábečný, Kamil Musílek, Ondřej Holas et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 64 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

Vendula Šepsová, Jana Žďárová Karasová, Jan Korábečný et al. · International Journal of Molecular Sciences · 2013 · 49 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Passive diffusion of acetylcholinesterase oxime reactivators through the blood–brain barrier: Influence of molecular structure

Jana Žďárová Karasová, Miroslav Pohanka, Kamil Musílek et al. · Toxicology in Vitro · 2010 · 38 citations

Life Sciences, Neuroscience, Pharmacology +17

Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain

Jana Žďárová Karasová, Filip Zemek, Jiří Bajgar et al. · Journal of Pharmaceutical and Biomedical Analysis · 2010 · 29 citations

Medicine, Pharmacokinetics, Pharmacology +8

Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment

Jan Korábečný, Kamil Musílek, Ondřej Holas et al. · Molecules · 2010 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16