Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption

David E. Clark · Journal of Pharmaceutical Sciences · 1999 · 618 citations

Pharmacy, Biophysics, Chemical Engineering +15

Time-Related Differences in the Physical Property Profiles of Oral Drugs

Paul D. Leeson, A. M. Davis · Journal of Medicinal Chemistry · 2004 · 325 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction

Scott Summerfield, Kevin D. Read, David J. Begley et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 284 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Pralidoxime Iodide (2-PAM) Penetrates Across the Blood-Brain Barrier

Koichi Sakurada, Kazuo Matsubara, Keiko Shimizu et al. · Neurochemical Research · 2003 · 193 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

The factors that influence permeation across the blood–brain barrier

Michael H. Abraham · European Journal of Medicinal Chemistry · 2004 · 149 citations

Life Sciences, Neuroscience, Pharmacokinetics +12