Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease

Shunsaku Nakagawa, Kumiko Nishihara, Hitomi Miyata, +11

PLoS ONE

Glomerular DiseaseMolecular MarkersRenal PathologyImmunologyPathology +17

Pralidoxime Iodide (2-PAM) Penetrates Across the Blood-Brain Barrier

Koichi Sakurada, Kazuo Matsubara, Keiko Shimizu, +7

Neurochemical Research

Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2

A. Reghan Foley, Manoj P. Menezes, Amelie Pandraud, +51

Brain

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisMendelian DisorderNeurological DisorderGenetic Disorder +12

Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases

Koji Aoyama, Kazuo Matsubara, Yasunori Fujikawa, +6

Annals of Neurology

Neurological DisorderLipid PeroxidationNeurochemical BiomarkersManganese Superoxide DismutaseRedox Biology +22

Potential bioactivated neurotoxicants, N-methylated β-carbolinium ions, are present in human brain

Kazuo Matsubara, Michael A. Collins, Atsushi Akane, +4

Brain Research

NeurotoxicologyN-methylated β-Carbolinium IonsBiochemistryNeurophysiologyMedicine +9

Endogenously Occurring β‐Carboline Induces Parkinsonism in Nonprimate Animals: A Possible Causative Protoxin in Idiopathic Parkinson's Disease

Kazuo Matsubara, Tatsuo Gonda, Hideyuki Sawada, +6

Journal of Neurochemistry

A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain

Wakako Maruyama, Gen Sobue, Kazuo Matsubara, +3

Neuroscience Letters

Oxidation ProductNeurophysiologyNeuroanatomyMedicineDopaminergic Neurotoxin +9

Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models

Haruka Nakanishi, Atsushi Yonezawa, Kazuo Matsubara, +1

European Journal of Pharmacology

Antiepileptic DrugsMedicineKnockout Mouse ModelsNeuropharmacologyExperimental Pharmacology +9

N-methyl(r)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity

Wakako Maruyama, P. Dostert, Kazuo Matsubara, +1

Free Radical Biology and Medicine

BiochemistryMedicineRadical (Chemistry)NeuroprotectionReactive Oxygen Specie +3

Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms

Satoshi Imai, Madoka Koyanagi, Ziauddin Azimi, +11

Scientific Reports