Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, +9

JCI Insight

Glutathione Peroxidase 4Lipid PeroxidationPathologyCell DeathDox-fe2+ Complex +15

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

Masataka Ikeda, Tomomi Ide, Takeo Fujino, +9

PLoS ONE

Mitochondrial event as an ultimate step in ferroptosis

Soo Jin Oh, Masataka Ikeda, Tomomi Ide, +2

Cell Death Discovery

Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury

Hiroko Deguchi Miyamoto, Masataka Ikeda, Tomomi Ide, +12

JACC Basic to Translational Science

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis

Ko Abe, Masataka Ikeda, Tomomi Ide, +12

Science Signaling

Lipid PeroxidationMolecular BiologyChemical BiologyRedox BiologyOxidative Stress +15

ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts

Nobuyuki Enzan, Shouji Matsushima, Soichiro Ikeda, +17

Circulation Research

Home-Based Cardiac Rehabilitation Using Information and Communication Technology for Heart Failure Patients with Frailty

Yuta Nagatomi, Tomomi Ide, Tae Higuchi, +16

ESC Heart Failure

Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity

Keita Saku, Takuya Kishi, Kazuo Sakamoto, +7

Physiological Reports

Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice

Hiroko Deguchi, Masataka Ikeda, Tomomi Ide, +7

Circulation Journal

Comparative mechanistic study of RPE cell death induced by different oxidative stresses

Yao Tong, Yinga Wu, Jing Ma, +5

Redox Biology