Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, +9

JCI Insight

Glutathione Peroxidase 4Lipid PeroxidationPathologyCell DeathDox-fe2+ Complex +15

Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury

Hiroko Deguchi Miyamoto, Masataka Ikeda, Tomomi Ide, +12

JACC Basic to Translational Science

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis

Ko Abe, Masataka Ikeda, Tomomi Ide, +12

Science Signaling

Lipid PeroxidationMolecular BiologyChemical BiologyRedox BiologyOxidative Stress +15

Acute Lymphocytic Myocarditis With Anti-PD-1 Antibody Nivolumab

Tomonori Tadokoro, Eri Keshino, Akitaka Makiyama, +4

Circulation Heart Failure

VasculitisAutoimmune DiseaseImmunologyPathologyAutoantibodies +4

ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts

Nobuyuki Enzan, Shouji Matsushima, Soichiro Ikeda, +17

Circulation Research

Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice

Hiroko Deguchi, Masataka Ikeda, Tomomi Ide, +7

Circulation Journal

Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Soichiro Ikeda, Shouji Matsushima, Kosuke Okabe, +10

Scientific Reports

DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)–Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1–Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway

Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, +10

Hypertension

HypertensionCardiovascular PharmacologyGlucagon-like PeptideAng IiCardiovascular Function +17

Excessive Hypoxia‐Inducible Factor‐1α Expression Induces Cardiac Rupture via p53‐Dependent Apoptosis After Myocardial Infarction

Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, +10

Journal of the American Heart Association

P53‐dependent ApoptosisApoptosisCell DeathPathologySevere Hypoxia +16

Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity

Tomonori Tadokoro, Masataka Ikeda, Ko Abe, +11

Journal of Cardiovascular Pharmacology