Herbert W. Virgin

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 4.7K citations · Full text

Systems Biology, Off-target Effect, Natural Sciences +10

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

Dora Pinto, Young‐Jun Park, Martina Beltramello et al. · Nature · 2020 · 2.1K citations · Full text

Vaccine Target, Immunology, Antibody Engineering +2

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

Luca Piccoli, Young‐Jun Park, M. Alejandra Tortorici et al. · Cell · 2020 · 1.6K citations · Full text

Structure-guided High-resolution Serology, Virus Structure, Immunodominant Sites +5

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Ken Cadwell, John Y. Liu, Sarah L. Brown et al. · Nature · 2008 · 1.5K citations · Full text

Autophagy Gene Atg16l1, Mitophagy, Cell Autophagy +9

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

Jason M. Norman, Scott A. Handley, Megan T. Baldridge et al. · Cell · 2015 · 1.3K citations · Full text

Inflammation, Autoimmune Disease, Mucosal Immunology +9