Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, +8

Proceedings of the National Academy of Sciences

GeneticsGenomicsGene RecognitionBioinformatics DatabaseGene Expression Profiling +21

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton, David Clayton, Lon R. Cardon, +32

Nature

Genome-wide Association StudyDisease SusceptibilityDisease EtiologyGlobal HealthGenetic Epidemiology +7

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer

Cell

Cell AutophagyMitophagyAutoimmune DiseaseAutoantibody ProductionPathogenesis +8

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui, +8

Nature

Neural CellsCell AutophagyNeurodegenerative DiseasesMitophagyAutophagy +10

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant, +20

Science

InflammationChronic Inflammatory DiseasesAutoimmune DiseaseMucosal ImmunologyImmunology +11

The role of autophagy during the early neonatal starvation period

Akiko Kuma, Masahiko Hatano, Makoto Matsui, +6

Nature

NutritionMitophagyEnergy HomeostasisDevelopmental BiologyCell Autophagy +6

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

Masaaki Komatsu, Satoshi Waguri, Masato Koike, +22

Cell

Cell AutophagyMitophagyDevelopmental BiologyAutophagy-deficient MiceAutophagy +8

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Jochen Hampe, André Franke, Philip Rosenstiel, +18

Nature Genetics

Genome-wide Association StudyNonsynonymous SnpsCrohn DiseaseGeneticsImmunology +7

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

John D. Rioux, Ramnik J. Xavier, Kent D. Taylor, +22

Nature Genetics

Genome-wide Association StudyCell AutophagyDisease MechanismDisease EtiologyCrohn Disease +8

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Koichi S. Kobayashi, Mathias Chamaillard, Yasunori Ogura, +4

Science

Nod2 ProteinInnate Immune SystemImmune RegulationImmunologyPathology +17