Caila Ryan

TET2 coactivates gene expression through demethylation of enhancers

Lu Wang, Patrick A. Ozark, Edwin R. Smith et al. · Science Advances · 2018 · 153 citations · Full text

Epigenetic Change, Genetics, Dna Methylation +18

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Andrea Piunti, Edwin R. Smith, Marc A. Morgan et al. · Science Advances · 2019 · 118 citations · Full text

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

Delphine Douillet, Christie C. Sze, Caila Ryan et al. · Nature Genetics · 2020 · 111 citations · Full text

Histone Modifications, Chromatin, Histone H3k4 Trimethylation +14

Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia

Lu Wang, Noah W. Birch, Zibo Zhao et al. · Nature Cancer · 2021 · 75 citations

Hematological Malignancy, Asxl1 Gain-of-function, Mixed-phenotype Acute Leukemia +5

Coordinated regulation of cellular identity–associated H3K4me3 breadth by the COMPASS family

Christie C. Sze, Patrick A. Ozark, Kaixiang Cao et al. · Science Advances · 2020 · 65 citations · Full text

Histone Modifications, Molecular Regulation, Epigenetic Change +22