An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

Henry R. Maun, Janet Jackman, David F. Choy, +47

Cell

AsthmaAllergyAllergy MedicineMast Cell DisorderImmunology +5

IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis

A. Francesca Setiadi, Alexander R. Abbas, Surinder Jeet, +11

Journal of Neuroimmunology

Neurological DisorderImmunologyImmune RegulationImmunologic MechanismBbb Integrity +18

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis

Arna Katewa, Yugang Wang, Jason A. Hackney, +29

JCI Insight

Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834

Wendy B. Young, J A Barbosa, Peter Blomgren, +25

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +9

Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC‐0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor

Ann Herman, Leslie W. Chinn, Shweta G. Kotwal, +14

Clinical Pharmacology & Therapeutics

The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase α is mediated by hydrogen peroxide

Michael P. Bova, Matthew N. Mattson, Stefan Vasile, +7

Archives of Biochemistry and Biophysics

Redox SignalingBiochemistryOrtho-quinone InhibitorsMedicineReactive Oxygen Specie +6

Discovery of highly potent and selective Bruton’s tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Wendy B. Young, J A Barbosa, Peter Blomgren, +25

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPyridazinone AnalogsBiochemistryMedicineNatural Sciences +10

The Minimal Essential Core of a Cysteine-based Protein-tyrosine Phosphatase Revealed by a Novel 16-kDa VH1-like Phosphatase, VHZ

Andrés Alonso, Stephen Burkhalter, Joanna M. Sasin, +7

Journal of Biological Chemistry

Viral ReplicationGeneticsMolecular BiologySurface Charge DistributionName Vhz +19

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

Xiaojing Wang, J A Barbosa, Peter Blomgren, +30

ACS Medicinal Chemistry Letters

VHY, a Novel Myristoylated Testis-restricted Dual Specificity Protein Phosphatase Related to VHX

Andrés Alonso, Sonoko Narisawa, Jori Bogetz, +9

Journal of Biological Chemistry