Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

Juliane Bubeck Wardenburg, Chong Fu, Janet Jackman, +7

Journal of Biological Chemistry

Signal TransductionCell RegulationSignaling PathwayG Protein-coupled ReceptorMedicine +11

T _H 2 and T _H 17 inflammatory pathways are reciprocally regulated in asthma

David F. Choy, Kevin M. Hart, Lee A. Borthwick, +22

Science Translational Medicine

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyImmune Regulation +18

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

Janet Jackman, David G. Motto, Qiming Sun, +5

Journal of Biological Chemistry

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

Aarti Shikotra, David F. Choy, Chandra Ohri, +11

Journal of Allergy and Clinical Immunology

AsthmaAllergyLung InflammationImmunologyImmunologic Disease +4

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

Hans D. Brightbill, Surinder Jeet, Zhonghua Lin, +24

Journal of Clinical Investigation

AsthmaHumoral ResponseImmunologyAntigen ProcessingImmunotherapy +16

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

Henry R. Maun, Janet Jackman, David F. Choy, +47

Cell

AsthmaAllergyAllergy MedicineMast Cell DisorderImmunology +5

Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling

Janet Jackman, Yongmei Chen, Arthur Huang, +17

Journal of Biological Chemistry

In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

David G. Motto, Susan Ross, Janet Jackman, +4

Journal of Biological Chemistry

Vivo AssociationMolecular PhysiologySignal TransductionSignaling PathwayMedicine +10

Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines

Christoph Spiess, Jack Bevers, Janet Jackman, +21

Journal of Biological Chemistry

Autoimmune DiseaseAllergyHuman Bispecific AntibodiesBispecific AntibodyImmunodeficiencies +13

Endogenously Expressed IL-13Rα2 Attenuates IL-13–Mediated Responses but Does Not Activate Signaling in Human Lung Fibroblasts

Sanjay Chandriani, Daryle J. DePianto, Elsa N N'Diaye, +14

The Journal of Immunology