Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

Ling Huang, Audrey Holtzinger, Ishaan Jagan, +18

Nature Medicine

Induced Pluripotent Stem CellPatient-derived Tumor OrganoidsEngineeringPancreatic CancerMedicine +10

Rfx6 directs islet formation and insulin production in mice and humans

Stuart B. Smith, Hui‐Qi Qu, Nadine Taleb, +25

Nature

Metabolic SyndromeInsulin ProductionInsulin SignalingIslet FormationPhysiology +8

Structural and functional changes resulting from islet isolation lead to islet cell death

Lawrence Rosenberg, Rennian Wang, Steven Paraskevas, +1

Surgery

Insulin ManagementDiabetesImmunologyCell DeathIslet Isolation Lead +5

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

Danna M. Breen, Brittany A. Rasmussen, Andrea Kokorovic, +3

Nature Medicine

NutritionDiabetes ManagementLower Glucose ConcentrationsPhysiologyClinical Nutrition +9

A Pentadecapeptide Fragment of Islet Neogenesis-Associated Protein Increases Beta-Cell Mass and Reverses Diabetes in C57BL/6J Mice

Lawrence Rosenberg, Mark Lipsett, Ji‐Won Yoon, +6

Annals of Surgery

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Pancreatic Islet α-Cells and Promotes Insulin Secretion

Yukihiro Fujita, Rhonda D. Wideman, Ali Asadi, +9

Gastroenterology

Pancreatic Islet α-CellsSignal TransductionMedicinePhysiologyPancreatic Islet Biology +6

β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival

Saira Saleem, Jinming Li, Siu‐Pok Yee, +3

The Journal of Pathology

Essential Role of <i>Pten</i> in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo

Kinh-Tung T. Nguyen, Panteha Tajmir, Chia Hung Lin, +12

Molecular and Cellular Biology

Activation and expression of ERK, JNK, and p38 MAP‐kinases in isolated islets of Langerhans: implications for cultured islet survival

Steven Paraskevas, Reid Aikin, Dušica Maysinger, +5

FEBS Letters

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

Ting Zhang, Dae Hyun Kim, Xiangwei Xiao, +12

Endocrinology