MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

Kensuke Kojima, Marina Konopleva, Ismael Samudio, +8

Blood

Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells

Yoko Tabe, Shinichi Yamamoto, Kaori Saitoh, +18

Cancer Research

Energy metabolism of leukemia cells: glycolysis<i>versus</i>oxidative phosphorylation

Kazuto Suganuma, Hiroshi Miwa, Norikazu Imai, +13

Leukemia & lymphoma/Leukemia and lymphoma

Chemoprevention StrategyLeukemia CellsMetabolic RemodelingWarburg EffectRedox Biology +14

Final 3-year Results of the Dasatinib Discontinuation Trial in Patients With Chronic Myeloid Leukemia Who Received Dasatinib as a Second-line Treatment

Masaya Okada, Jun Imagawa, Hideo Tanaka, +45

Clinical Lymphoma Myeloma & Leukemia

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

Kensuke Kojima, Masaya Shimanuki, Masato Shikami, +7

Leukemia

Mitochondrial FunctionMedicineP53 Wild-type AmlApoptosisCell Death +8

TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment

Yoko Tabe, Yue Shi, Zhihong Zeng, +7

PLoS ONE

Importance of Glutamine Metabolism in Leukemia Cells by Energy Production Through TCA Cycle and by Redox Homeostasis

Mineaki Goto, Hiroshi Miwa, Masato Shikami, +7

Cancer Investigation

Chemoprevention StrategyMetabolic RemodelingRedox HomeostasisRedox BiologyOxidative Stress +18

Survival of human leukaemic B‐cell precursors is supported by stromal cells and cytokines: association with the expression of <i>bcl‐2</i> protein

Kazuhiro Nishii, Naoyuki Katayama, Hiroshi Miwa, +4

British Journal of Haematology

Stromal CellsMixed-phenotype Acute LeukemiaImmunologyCell DeathPathology +14

Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress

Mineaki Goto, Hiroshi Miwa, Kazuto Suganuma, +6

BMC Cancer

Cyclin‐dependent kinase 1 inhibitor RO‐3306 enhances p53‐mediated Bax activation and mitochondrial apoptosis in AML

Kensuke Kojima, Masaya Shimanuki, Masato Shikami, +2

Cancer Science

Chemoprevention StrategyApoptosisCell DeathTumor BiologyAutophagy +15