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The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

Mitochondrial FunctionMedicineP53 Wild-type AmlApoptosisCell DeathMdm2 InhibitionP53-mediated Mitochondrial ApoptosisTumor SuppressorRadiation OncologyOncologyCell BiologyCancer ResearchTumor Biology