David L. Shen

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

T.M. Gloster, Wesley F. Zandberg, Julia Heinonen et al. · Nature Chemical Biology · 2011 · 319 citations

Biosynthesis, Signal Transduction, Cellular Enzymology +11

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation

C. Martinez-Fleites, Matthew S. Macauley, Yuan He et al. · Nature Structural & Molecular Biology · 2008 · 114 citations

Glycoproteomics, Protein Glycosylation, O-glcnac Transferase Homolog +8

Insights into O-Linked N-Acetylglucosamine ([0-9]O-GlcNAc) Processing and Dynamics through Kinetic Analysis of O-GlcNAc Transferase and O-GlcNAcase Activity on Protein Substrates

David L. Shen, T.M. Gloster, Scott A. Yuzwa et al. · Journal of Biological Chemistry · 2012 · 114 citations · Full text

Biochemistry, Natural Sciences, Enzyme Catalysis +9

Development of a novel mammalian cell surface antibody display platform

Chen Zhou, Frederick W. Jacobsen, Ling Cai et al. · mAbs · 2010 · 90 citations · Full text

Immunocytochemical Technique, Engineering, Biomedical Diagnostics +14

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

S. Kolappan, David L. Shen, Renée Mosi et al. · Acta Crystallographica Section D Biological Crystallography · 2015 · 76 citations

Molecular Biology, Molecular Pharmacology, Structure-function Enzyme Kinetics +17