Novel Inhibitors of DNA Gyrase:  3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

Hans-Joachim Boehm, Markus Boehringer, Daniel Bur, +8

Journal of Medicinal Chemistry

Drug TargetBiochemistryHit ValidationMedicineAtp Binding Site +13

DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro

Marcha Verheijen, Matthias Lienhard, Yannick Schrooders, +12

Scientific Reports

The exposome in practice: Design of the EXPOsOMICS project

Paolo Vineis, Marc Chadeau‐Hyam, Hans Gmuender, +11

International Journal of Hygiene and Environmental Health

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

Heidrun Ellinger‐Ziegelbauer, Hans Gmuender, Arnd Bandenburg, +1

Mutation research. Fundamental and molecular mechanisms of mutagenesis

HepatologyToxicogenomics AnalysisPredictive ToxicologyMedicineLiver Physiology +10

Gene Expression Changes Triggered by Exposure of <i>Haemophilus influenzae</i> to Novobiocin or Ciprofloxacin: Combined Transcription and Translation Analysis

Hans Gmuender, Karin Kuratli, Karin Di Padova, +3

Genome Research

Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases

Ayoung Jeong, Giovanni Fiorito, Pekka Keski‐Rahkonen, +21

Environment International

Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Andrea Rössnerová, Elena Tulupová, Nana Tabashidze, +5

Mutation research. Fundamental and molecular mechanisms of mutagenesis

AsthmaChromatinEpigenetic ChangeGeneticsEnvironmental Health +11

EU Framework 6 Project: Predictive Toxicology (PredTox)—overview and outcome

Laura Suter‐Dick, Susanne Schroeder, Kirstin Meyer, +9

Toxicology and Applied Pharmacology

Predictive ToxicologyEnvironmental HealthToxicologyEnvironmental ToxicologyPublic Health +2

A New DNA Gyrase Inhibitor Subclass of the Cyclothialidine Family Based on a Bicyclic Dilactam−Lactone Scaffold. Synthesis and Antibacterial Properties

Peter Angehrn, Erwin Goetschi, Hans Gmuender, +7

Journal of Medicinal Chemistry

Antimicrobial ChemotherapyBicyclic Dilactam−lactone ScaffoldPharmaceutical ChemistryDrug ResistanceCyclothialidine Family +15

Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity

Reha Yildirimman, Gabriella Brolén, Mireia Vilardell, +11

Toxicological Sciences

Chemical CarcinogenicityGene Expression ProfilingToxicological MechanismGene Expression MicroarraysChemical Carcinogenesis +21