Immanuel F. Luescher

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

Julien Fourcade, Zhaojun Sun, Mourad Benallaoua et al. · The Journal of Experimental Medicine · 2010 · 1.3K citations · Full text

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

Catia Traversari, Pierre van der Bruggen, Immanuel F. Luescher et al. · The Journal of Experimental Medicine · 1992 · 694 citations · Full text

Hla, Histocompatibility, Hla Immunogenetics +20

CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1

Julien Fourcade, Zhaojun Sun, Ornella Pagliano et al. · Cancer Research · 2011 · 362 citations · Full text

Inhibitory Receptors Btla, T-regulatory Cell, Immunology +25

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

Alexis M. Kalergis, Nicole Boucheron, Marie‐Agnès Doucey et al. · Nature Immunology · 2001 · 321 citations

Signal Transduction, T-regulatory Cell, Immunology +11

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

Daniel T. Utzschneider, Amandine Legat, Silvia A. Fuertes Marraco et al. · Nature Immunology · 2013 · 271 citations

Antigen Withdrawal, Autoimmune Disease, Adaptive Immune System +10