Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew, +46

Journal of Medicinal Chemistry

Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer.

Wen‐Feng Fang, N. R. Hartmann, David Chow, +2

Journal of Biological Chemistry

ImmunologyPathologyCell ProliferationCancer BiologyCellular Physiology +16

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Yosup Rew, Daqing Sun, Felix González-López de Turiso, +32

Journal of Medicinal Chemistry

Synthetic group A streptogramin antibiotics that overcome Vat resistance

Qi Li, J. Pellegrino, D. John Lee, +19

Nature

Vat ResistanceAntibioticsMedicineMicrobiologyAntibiotic Resistance +3

Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction

Ana Z. González, John Eksterowicz, Michael D. Bartberger, +33

Journal of Medicinal Chemistry

Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors

Felix González-López de Turiso, Daqing Sun, Yosup Rew, +27

Journal of Medicinal Chemistry

Potent Mdm2 InhibitorsDrug TargetMolecular BiologyTumor BiologyMolecular Pharmacology +15

Ferredoxin from sweet pepper (Capsicum annuum L.) intensifying harpinpss-mediated hypersensitive response shows an enhanced production of active oxygen species (AOS)

B. V. Dayakar, Hao-Jan Lin, Cheng‐Hsien Chen, +8

Plant Molecular Biology

Pseudomonas aeruginosa B-band O-antigen chain length is modulated by Wzz (Ro1)

Lori L. Burrows, David Chow, Joseph S. Lam

Journal of Bacteriology

Medical MicrobiologyChain LengthsChain Length ModulationVirulence FactorPathogenesis +11

Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres

Ana Z. González, Zhihong Li, Hilary P. Beck, +31

Journal of Medicinal Chemistry

Medicinal ChemistryMdm2-p53 InteractionDrug TargetBiochemistryNatural Sciences +13

cDNA cloning and characterization of a plant protein that may be associated with the harpinPSS-mediated hypersensitive response

Cheng‐Hsien Chen, Hao-Jan Lin, Mang-jye Ger, +2

Plant Molecular Biology