Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

Chi Nguyen, Robert W. Haushalter, D. John Lee, +11

Nature

BiosynthesisBiochemistryNatural SciencesProtein BiosynthesisMolecular Biology +3

Synthetic group A streptogramin antibiotics that overcome Vat resistance

Qi Li, J. Pellegrino, D. John Lee, +19

Nature

Vat ResistanceAntibioticsMedicineMicrobiologyAntibiotic Resistance +3

Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics

Kaitlyn Tsai, Vanja Stojković, D. John Lee, +7

Nature Structural & Molecular Biology

Inhibitory ActivityBiochemistryAntibioticsMedicineMechanism Of Action +7

Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL

M. Jaremko, D. John Lee, Stanley J. Opella, +1

Journal of the American Chemical Society

Protein SecretionProtein AssemblyMolecular BiologyType Ii NrpssChemical Biology +16

Molecular basis for interactions between an acyl carrier protein and a ketosynthase

Jacob C. Milligan, D. John Lee, David R. Jackson, +7

Nature Chemical Biology

Acyl Carrier ProteinBiosynthesisCellular EnzymologyBiochemistryProtein Function +5

Sulfonyl 3-Alkynyl Pantetheinamides as Mechanism-Based Cross-Linkers of Acyl Carrier Protein Dehydratase

Fumihiro Ishikawa, Robert W. Haushalter, D. John Lee, +2

Journal of the American Chemical Society

BiosynthesisAldehyde DehydrogenaseAldo-keto ReductaseBiochemistryCross-link +11

Modeling Linear and Cyclic PKS Intermediates through Atom Replacement

Gaurav Shakya, Heriberto Rivera, D. John Lee, +13

Journal of the American Chemical Society

Protein AssemblyProton-coupled Electron TransferMolecular BiologyComputational ChemistryChemistry +19

Decoding allosteric regulation by the acyl carrier protein

Terra Sztain, Thomas G. Bartholow, D. John Lee, +6

Proceedings of the National Academy of Sciences

Acyl Carrier ProteinBiosynthesisSignal TransductionBiochemistryAppropriate Enzyme +11

Elucidation of transient protein-protein interactions within carrier protein-dependent biosynthesis

Thomas G. Bartholow, Terra Sztain, Ashay Patel, +4

Communications Biology

Modifying the Thioester Linkage Affects the Structure of the Acyl Carrier Protein

Terra Sztain, Ashay Patel, D. John Lee, +3

Angewandte Chemie International Edition

Protein ChemistryBiosynthesisAcyl Carrier ProteinBiochemistryProtein Assembly +13