Jonathan L. Papa

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with <i>In Vivo</i> Efficacy against MRSA

Yanran Lu, Sandip Vibhute, Linsen Li et al. · Journal of Medicinal Chemistry · 2021 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive <i>Staphylococcus aureus</i>

Yanran Lu, Jonathan L. Papa, Sheri Nolan et al. · ACS Medicinal Chemistry Letters · 2020 · 24 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide

Evan E. Kania, Jessika Carvajal‐Moreno, Vı́ctor Agmo Hernández et al. · Molecular Pharmacology · 2019 · 23 citations · Full text

Medicine, Molecular Biology, Oncology +16

CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells

Vı́ctor Agmo Hernández, Jessika Carvajal‐Moreno, Jonathan L. Papa et al. · Molecular Pharmacology · 2021 · 16 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Novel bacterial topoisomerase inhibitors derived from isomannide

Antony A. Okumu, Yanran Lu, Sheri Dellos-Nolan et al. · European Journal of Medicinal Chemistry · 2020 · 14 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +9