Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Stewart T. Cole, Roland Brosch, Julian Parkhill, +39

Nature

Pulmonary TuberculosisComplete Genome SequenceMycobacterium TuberculosisBacteriologyMolecular Biology +8

A new evolutionary scenario for the <i>Mycobacterium tuberculosis</i> complex

Roland Brosch, Stephen V. Gordon, Magali Marmiesse, +11

Proceedings of the National Academy of Sciences

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines <i>Mycobacterium bovis</i> BCG and <i>Mycobacterium microti</i>

Alexander S. Pym, Priscille Brodin, Roland Brosch, +2

Molecular Microbiology

Microbial PathogensTuberculosis PreventionImmunologyHumoral ResponseMycobacterium Microti +15

Benzothiazinones Kill <i>Mycobacterium tuberculosis</i> by Blocking Arabinan Synthesis

Vadim Makarov, Giulia Manina, Katarı́na Mikus̃ová, +34

Science

Bioorganic ChemistryMajor Btz TargetAntimicrobial ChemotherapyPharmaceutical ChemistryDrug Resistance +16

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

Alexander S. Pym, Priscille Brodin, Laleh Majlessi, +7

Nature Medicine

Medical MicrobiologyPulmonary TuberculosisPathogenesisImmunologyTuberculosis Prevention +5

Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis

M. Cristina Gutiérrez, Sylvain Brisse, Roland Brosch, +5

PLoS Pathogens

Comparative GenomicsGeneticsBacteriologyEast AfricaMolecular Genetics +21

Genome plasticity of BCG and impact on vaccine efficacy

Roland Brosch, Stephen V. Gordon, Thierry Garnier, +17

Proceedings of the National Academy of Sciences

VaccinationBcg PasteurGenome PlasticityVaccine DevelopmentMicrobial Pathogens +11

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

Roxane Siméone, Alexandre Bobard, Juliane Lippmann, +4

PLoS Pathogens

Microbial PathogensTuberculosis PreventionImmunologyImmune RegulationAntigen Processing +19

Insights from the complete genome sequence of <i>Mycobacterium marinum</i> on the evolution of <i>Mycobacterium tuberculosis</i>

Timothy P. Stinear, Torsten Seemann, Paul F. Harrison, +28

Genome Research

Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays

Stephen V. Gordon, Roland Brosch, Alain Billault, +3

Molecular Microbiology