Brian P. Boscoe

Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides

Jennie Liao, Corey H. Basch, Megan E. Hoerrner et al. · Organic Letters · 2019 · 165 citations · Full text

Heterocycle Tolerance, Chemical Engineering, Cross-coupling Reaction +11

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 138 citations · Full text

Transforming Benzylic Amines into Diarylmethanes: Cross-Couplings of Benzylic Pyridinium Salts via C–N Bond Activation

Jennie Liao, Weiye Guan, Brian P. Boscoe et al. · Organic Letters · 2018 · 127 citations · Full text

Arylboronic Acids, Benzylic Amines, Chemical Engineering +11

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 <i>H</i> -pyrazolo-[3,4- <i>b</i> ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

Lei Zhang, Gayatri Balan, Gabriela Barreiro et al. · Journal of Medicinal Chemistry · 2014 · 51 citations · Full text

The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells.

Elsa G. Barbacci, Leslie R. Pustilnik, Ann Marie Rossi et al. · PubMed · 2003 · 46 citations

Breast Oncology, Chemoprevention Strategy, Cell Death +16